Wybrane publikacje
G. Detlaff, M. Zdrowowicz, M. Paduszyńska, M. Datta, D. Grzywacz, W. Kamysz, J. Rak, A. Nowacki, H. Myszka, B. Liberek
Insight into the Course of the Ferrier Rearrangement Used to Obtain Untypical Diosgenyl Saponins
J. Org. Chem., 2024, 89, 15026.
D. Grzywacz, H. Myszka, B. Liberek
Synthesis, modification and biological activity of diosgenyl β-D-glycosaminosides: an overview
Molecules, 2020, 25, 5433.
M. Reszka, I.E. Serdiuk, K. Kozakiewicz, A. Nowacki, H. Myszka, P. Bojarski, B. Liberek
Influence of a 4-substituent on the efficiency of flavonol-based fluorescent indicators of β-glycosidase activity
Org. Biomol. Chem., 2020, 18, 7635.
H. Myszka, D. Grzywacz, M. Zdrowowicz, P. Spisz, K. Butowska, J. Rak, J. Piosik, M. Jakiewicz, W. Kamysz, B. Liberek
Design, synthesis and biological evaluation of betulin-3-yl 2-amino-2-deoxy-β-D-glycopyranosides
Bioorg. Chem., 2020, 96, 103568.
D. Grzywacz, M. Paduszyńska, M. Norkowska, W. Kamysz, H. Myszka, B. Liberek
N-Aminoacyl and N-hydroxyacyl derivatives of diosgenyl 2-amino-2-deoxy-β-D-gluco-pyranoside: Synthesis, antimicrobial and hemolytic activities
Bioorg. Med. Chem., 2019, 27, 114923.
J. Wielińska, J. Bednarko, H. Myszka, B. Liberek, A. Nowacki
Cyclophosphamide and isophosphamide - DFT conformational studies in the gas phase and solution
J. Mol. Graph. Model., 2019, 90, 243.
M.A. Dawgul, D. Grzywacz, B. Liberek, W. Kamysz, H. Myszka
Activity of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside, its hydrochloride, and N,N-dialkyl derivatives against non-albicans Candida isolates
Med. Chem., 2018, 14, 460.
H. Myszka, P. Sokołowska, A. Cieślińska, A. Nowacki, M. Jaśkiewicz, W. Kamysz, B. Liberek
Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
Beilstein J. Org. Chem., 2017, 13, 2310.
D. Walczak, A. Nowacki, D. Trzybiński, J. Samaszko-Fiertek, H. Myszka, A. Sikorski, B. Liberek
Conformational studies of N-(α-D-glucofuranurono-6,3-lactone)- and N-(methyl β-D-glucopyranuronate)-p-nitroanilines
Carbohydr. Res., 2017, 446-447, 85.
M. Cyman, J. Wielińska, H. Myszka, D. Trzybiński, A. Sikorski, A. Nowacki, B. Liberek
Influence of the oxime and anomeric configurations on the stability of 2-deoxy-2-hydroxyimino-D-hexopyranosides
J. Molc. Struct., 2016, 1125, 558.
I.E. Serdiuk, M. Reszka, H. Myszka, K. Krzymiński, B. Liberek, A.D. Roshal
Flavonol-based fluorescent indicator for determination of β-glucosidase activity
RSC Adv., 2016, 6, 42532.
A. Walczewska, D. Grzywacz, D. Bednarczyk, M. Dawgul, A. Nowacki, W. Kamysz, B. Liberek, H. Myszka
N-Alkyl derivatives of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside; synthesis and antimicrobial activity
Beilstein J. Org. Chem., 2015, 11, 869.
M. Norkowska, H. Myszka, M. Cyman, D. Grzywacz, D. Trzybiński, A. Sikorski, B. Liberek
2,3,4,6-Tetra-O-acetyl-D-gluconic acid: crystal structure and application in the synthesis of N-(D-gluconyl) derivatives of D-glucosamine
J. Carbohydr. Chem., 2014, 33, 33.
A. Nowacki, H. Myszka, B. Liberek
Conformational studies of diosgenyl 2-amino-2-deoxy-β-D-glucopyranosides at the PM3 and DFT levels of theory
Carbohydr. Res., 2013, 377, 4.
D. Bednarczyk, A. Walczewska, D. Grzywacz, A. Sikorski, B. Liberek, H. Myszka
Differently N-protected 3,4,6-tri-O-acetyl-2-amino-2-deoxy-D-glucopyranosyl chlorides and their application in the synthesis of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside.
Carbohydr. Res., 2013, 367, 10.
D. Grzywacz, M. Dawgul, W. Kamysz, B. Liberek, H. Myszka
Synteza i aktywność mikrobiologiczna N-acylowych pochodnych 2-amino-2-deoksy-β-D-glukopiranozydu diosgenylu.
Na pograniczu chemii i biologii - Wydawnictwo Naukowe UAM, Poznań, ISBN 978-83-232-2683-3
2013, Tom XXXI, 83.
O. Cirioni, H. Myszka, M. Dawgul, R. Ghiselli, F. Orlando, C. Silvestri, L. Brescini, W. Kamysz, M. Guerrieri, A. Giacometti
In vitro activity and in vivo efficacy of the saponin diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside hydrochloride (HSM1) alone and in combination with daptomycin and vancomycin against Gram-positive cocci.
J. Med. Microbiol., 2011, 60, 1337.
A. Janowska, H. Myszka, A. Wiśniewski
Właściwości biologiczne saponin.
Na pograniczu chemii i biologii - Wydawnictwo Naukowe UAM, Poznań, ISBN 83-232-1968-2
2008, Tom XXI, 215.
A. Janowska, H. Myszka
Saponiny diosgeniny.
Na pograniczu chemii i biologii - Wydawnictwo Naukowe UAM, Poznań, ISBN 83-232-1625-8
2005, Tom XIII, 117.
H. Myszka, D. Bednarczyk
Saponiny steroidowe.
Wiad. Chem., 2005, 59, 275.
H. Myszka, D. Bednarczyk, M. Najder, W. Kaca
Synthesis and induction of apoptosis in B cell chronic leukemia by diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside hydrochloride and its derivatives.
Carbohydr. Res., 2003, 338, 133.
H. Myszka, D. Bednarczyk, Z. Ciunik, W. Kaca
1H and 13C NMR and X-ray diffraction data for a diosgenyl N,O-protected glucopyranoside.
Magn. Reson. Chem., 2002, 40, 231.
D. Bednarczyk, H. Myszka
Osłony grupy aminowej w D-glukozaminie.
Wiad. Chem., 2001, 55, 491.
H. Myszka, D. Bednarczyk, A. Winiewski, W. Kaca, Z. Ciunik
Synthesis of diosgenyl 2-deoxy-β-D-glucopyranoside hydrochloride derivatives and their anticancer properties.
Proceedings of 3rd International Conference of PhD Students, University of Miskolc - Hungary, Natural Science, 2001, 253-260; Published by University of Miskolc - Innovation and Technology Transfer Centre, ISBN 963 661 480 6, ISBN 963 661 486 5.
D. Bednarczyk, W. Kaca, H. Myszka, L. Serwecińska, Z. Smiatacz, A. Zaborowski
The synthesis of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside hydrochloride.
Carbohydr. Res., 2000, 328, 249.
Z. Smiatacz, I. Chrzczanowicz, H. Myszka
Chemical modification of some methyl (3,4-di-O-acetyl-2-deoxy-2-hydroxyimino-α-D-arabino-hexopyranosid)uronates.
Carbohydr. Res., 1997, 298, 341.
Insight into the Course of the Ferrier Rearrangement Used to Obtain Untypical Diosgenyl Saponins
J. Org. Chem., 2024, 89, 15026.
D. Grzywacz, H. Myszka, B. Liberek
Synthesis, modification and biological activity of diosgenyl β-D-glycosaminosides: an overview
Molecules, 2020, 25, 5433.
M. Reszka, I.E. Serdiuk, K. Kozakiewicz, A. Nowacki, H. Myszka, P. Bojarski, B. Liberek
Influence of a 4-substituent on the efficiency of flavonol-based fluorescent indicators of β-glycosidase activity
Org. Biomol. Chem., 2020, 18, 7635.
H. Myszka, D. Grzywacz, M. Zdrowowicz, P. Spisz, K. Butowska, J. Rak, J. Piosik, M. Jakiewicz, W. Kamysz, B. Liberek
Design, synthesis and biological evaluation of betulin-3-yl 2-amino-2-deoxy-β-D-glycopyranosides
Bioorg. Chem., 2020, 96, 103568.
D. Grzywacz, M. Paduszyńska, M. Norkowska, W. Kamysz, H. Myszka, B. Liberek
N-Aminoacyl and N-hydroxyacyl derivatives of diosgenyl 2-amino-2-deoxy-β-D-gluco-pyranoside: Synthesis, antimicrobial and hemolytic activities
Bioorg. Med. Chem., 2019, 27, 114923.
J. Wielińska, J. Bednarko, H. Myszka, B. Liberek, A. Nowacki
Cyclophosphamide and isophosphamide - DFT conformational studies in the gas phase and solution
J. Mol. Graph. Model., 2019, 90, 243.
M.A. Dawgul, D. Grzywacz, B. Liberek, W. Kamysz, H. Myszka
Activity of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside, its hydrochloride, and N,N-dialkyl derivatives against non-albicans Candida isolates
Med. Chem., 2018, 14, 460.
H. Myszka, P. Sokołowska, A. Cieślińska, A. Nowacki, M. Jaśkiewicz, W. Kamysz, B. Liberek
Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
Beilstein J. Org. Chem., 2017, 13, 2310.
D. Walczak, A. Nowacki, D. Trzybiński, J. Samaszko-Fiertek, H. Myszka, A. Sikorski, B. Liberek
Conformational studies of N-(α-D-glucofuranurono-6,3-lactone)- and N-(methyl β-D-glucopyranuronate)-p-nitroanilines
Carbohydr. Res., 2017, 446-447, 85.
M. Cyman, J. Wielińska, H. Myszka, D. Trzybiński, A. Sikorski, A. Nowacki, B. Liberek
Influence of the oxime and anomeric configurations on the stability of 2-deoxy-2-hydroxyimino-D-hexopyranosides
J. Molc. Struct., 2016, 1125, 558.
I.E. Serdiuk, M. Reszka, H. Myszka, K. Krzymiński, B. Liberek, A.D. Roshal
Flavonol-based fluorescent indicator for determination of β-glucosidase activity
RSC Adv., 2016, 6, 42532.
A. Walczewska, D. Grzywacz, D. Bednarczyk, M. Dawgul, A. Nowacki, W. Kamysz, B. Liberek, H. Myszka
N-Alkyl derivatives of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside; synthesis and antimicrobial activity
Beilstein J. Org. Chem., 2015, 11, 869.
M. Norkowska, H. Myszka, M. Cyman, D. Grzywacz, D. Trzybiński, A. Sikorski, B. Liberek
2,3,4,6-Tetra-O-acetyl-D-gluconic acid: crystal structure and application in the synthesis of N-(D-gluconyl) derivatives of D-glucosamine
J. Carbohydr. Chem., 2014, 33, 33.
A. Nowacki, H. Myszka, B. Liberek
Conformational studies of diosgenyl 2-amino-2-deoxy-β-D-glucopyranosides at the PM3 and DFT levels of theory
Carbohydr. Res., 2013, 377, 4.
D. Bednarczyk, A. Walczewska, D. Grzywacz, A. Sikorski, B. Liberek, H. Myszka
Differently N-protected 3,4,6-tri-O-acetyl-2-amino-2-deoxy-D-glucopyranosyl chlorides and their application in the synthesis of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside.
Carbohydr. Res., 2013, 367, 10.
D. Grzywacz, M. Dawgul, W. Kamysz, B. Liberek, H. Myszka
Synteza i aktywność mikrobiologiczna N-acylowych pochodnych 2-amino-2-deoksy-β-D-glukopiranozydu diosgenylu.
Na pograniczu chemii i biologii - Wydawnictwo Naukowe UAM, Poznań, ISBN 978-83-232-2683-3
2013, Tom XXXI, 83.
O. Cirioni, H. Myszka, M. Dawgul, R. Ghiselli, F. Orlando, C. Silvestri, L. Brescini, W. Kamysz, M. Guerrieri, A. Giacometti
In vitro activity and in vivo efficacy of the saponin diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside hydrochloride (HSM1) alone and in combination with daptomycin and vancomycin against Gram-positive cocci.
J. Med. Microbiol., 2011, 60, 1337.
A. Janowska, H. Myszka, A. Wiśniewski
Właściwości biologiczne saponin.
Na pograniczu chemii i biologii - Wydawnictwo Naukowe UAM, Poznań, ISBN 83-232-1968-2
2008, Tom XXI, 215.
A. Janowska, H. Myszka
Saponiny diosgeniny.
Na pograniczu chemii i biologii - Wydawnictwo Naukowe UAM, Poznań, ISBN 83-232-1625-8
2005, Tom XIII, 117.
H. Myszka, D. Bednarczyk
Saponiny steroidowe.
Wiad. Chem., 2005, 59, 275.
H. Myszka, D. Bednarczyk, M. Najder, W. Kaca
Synthesis and induction of apoptosis in B cell chronic leukemia by diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside hydrochloride and its derivatives.
Carbohydr. Res., 2003, 338, 133.
H. Myszka, D. Bednarczyk, Z. Ciunik, W. Kaca
1H and 13C NMR and X-ray diffraction data for a diosgenyl N,O-protected glucopyranoside.
Magn. Reson. Chem., 2002, 40, 231.
D. Bednarczyk, H. Myszka
Osłony grupy aminowej w D-glukozaminie.
Wiad. Chem., 2001, 55, 491.
H. Myszka, D. Bednarczyk, A. Winiewski, W. Kaca, Z. Ciunik
Synthesis of diosgenyl 2-deoxy-β-D-glucopyranoside hydrochloride derivatives and their anticancer properties.
Proceedings of 3rd International Conference of PhD Students, University of Miskolc - Hungary, Natural Science, 2001, 253-260; Published by University of Miskolc - Innovation and Technology Transfer Centre, ISBN 963 661 480 6, ISBN 963 661 486 5.
D. Bednarczyk, W. Kaca, H. Myszka, L. Serwecińska, Z. Smiatacz, A. Zaborowski
The synthesis of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside hydrochloride.
Carbohydr. Res., 2000, 328, 249.
Z. Smiatacz, I. Chrzczanowicz, H. Myszka
Chemical modification of some methyl (3,4-di-O-acetyl-2-deoxy-2-hydroxyimino-α-D-arabino-hexopyranosid)uronates.
Carbohydr. Res., 1997, 298, 341.
Z. Smiatacz, I. Chrzczanowicz, H. Myszka, P. Dokurno
The synthesis and structure of selected methyl (3,4-di-O-acetyl-2-deoxy-2-hydroksyimino-D-arabino-hexopyranosid)uronates.
J. Carbohydr. Chem., 1995, 14, 723.
The synthesis and structure of selected methyl (3,4-di-O-acetyl-2-deoxy-2-hydroksyimino-D-arabino-hexopyranosid)uronates.
J. Carbohydr. Chem., 1995, 14, 723.
P. Dokurno, J. Łubkowski, H. Myszka, Z. Smiatacz
Crystal structures of N-aryl-N-pentopyranosylamines.
Zeitschr. für Kristallogr., 1994, 209, 808.
Crystal structures of N-aryl-N-pentopyranosylamines.
Zeitschr. für Kristallogr., 1994, 209, 808.
Z. Smiatacz, H. Myszka, A. Dąbrowska
Preparation of the 2-amino-D-galacto and D-talo-O-pyranosyl derivatives of L-serine, L-threonine and L-tyrosine from corresponding 2-hydroxyimino-D-lyxo-hexopyranosyl derivatives.
Bull. Pol. Ac. Sci. Chem., 1991, 39, 105.
Z. Smiatacz, H. Myszka
The synthesis, structure, and chemical transformation of methyl esters of O-(3,4-di-O-acetyl-2-deoxy-2-hydroxyimino-D-erythro-pentopyranosyl)-N-tosyl-L-serine, -L-threonine, and -L-tyrosine.
Carbohydr. Res., 1990, 196, 167.
Z. Ciunik, H. Paulsen, P. Luger, Z. Smiatacz, H. Myszka
Structures of two 2-oxyimino-α-D-pyranosides.
Acta Cryst., 1989, B45, 512.
Z. Smiatacz, H. Myszka
Chemical modification of 1-(3,4-di-O-acetyl-2-deoxy-2-hydroxyimino-α- and -β-D-erythro-pentopyranosyl)pyrazole at C-2 and C-3.
Carbohydr. Res., 1989, 186, 335.
Z. Smiatacz, H. Myszka, Z. Ciunik
Configuration and conformation of the products of reaction of 3,4-di-O-acetyl-2-deoxy-2-nitroso-β-D-arabinopyranosyl chloride with pyrazole.
Carbohydr. Res., 1988, 172, 171.
Preparation of the 2-amino-D-galacto and D-talo-O-pyranosyl derivatives of L-serine, L-threonine and L-tyrosine from corresponding 2-hydroxyimino-D-lyxo-hexopyranosyl derivatives.
Bull. Pol. Ac. Sci. Chem., 1991, 39, 105.
Z. Smiatacz, H. Myszka
The synthesis, structure, and chemical transformation of methyl esters of O-(3,4-di-O-acetyl-2-deoxy-2-hydroxyimino-D-erythro-pentopyranosyl)-N-tosyl-L-serine, -L-threonine, and -L-tyrosine.
Carbohydr. Res., 1990, 196, 167.
Z. Ciunik, H. Paulsen, P. Luger, Z. Smiatacz, H. Myszka
Structures of two 2-oxyimino-α-D-pyranosides.
Acta Cryst., 1989, B45, 512.
Z. Smiatacz, H. Myszka
Chemical modification of 1-(3,4-di-O-acetyl-2-deoxy-2-hydroxyimino-α- and -β-D-erythro-pentopyranosyl)pyrazole at C-2 and C-3.
Carbohydr. Res., 1989, 186, 335.
Z. Smiatacz, H. Myszka, Z. Ciunik
Configuration and conformation of the products of reaction of 3,4-di-O-acetyl-2-deoxy-2-nitroso-β-D-arabinopyranosyl chloride with pyrazole.
Carbohydr. Res., 1988, 172, 171.